Multi-user ArcGIS Pro for sensitive research data—what's working at scale?

We’re trying to provide shared ArcGIS Pro access to researchers working with high-risk data (PHI-adjacent, contractually confidential). Currently running persistent Azure VMs (bundles Windows OS license unlike AWS). Would be so much happier if ArcGIS Pro was HPC compatible :expressionless_face:

Constraints: Windows + GPU required, per-machine licensing, data can’t leave without approval.

Curious about:

  • VDI/Citrix/Custom pools with fair-share scheduling?

  • Concurrent-use licensing approaches that actually work for shared infrastructure?

  • Architectural patterns for sensitive data isolation without dedicated VMs per user?

Would love to hear what others have landed on—even solutions outside the sensitive data context. What’s actually working at scale?